Improving radiation therapy for prostate cancer using targeted molecules

Who could benefit from this research

What this research studies

This research focuses on enhancing the effectiveness of radiation therapy for prostate cancer by developing specialized molecules that target prostate-specific antigens. The approach involves creating two new compounds that link a PSMA ligand to radiation-sensitizing agents, which may improve the treatment's efficacy while minimizing damage to surrounding healthy tissues. The research will include laboratory tests on prostate cancer cell lines and animal models to evaluate how well these new compounds work and their potential side effects. Patients may benefit from improved treatment options that could lead to better outcomes and fewer complications.

Why it matters

Where this research is happening

• Sloan-Kettering Inst Can Research
  New York, United States Active

Researchers

• Principal investigator: Higginson, Daniel — Sloan-Kettering Inst Can Research
• Study coordinator: Higginson, Daniel

Related research

Other NIH-funded projects on the same topics.

• Reducing prostate cancer radiotherapy toxicity through genes and technology

  A study to find genetic clues that predict who will have side effects from prostate cancer radiotherapy and to use new tools to reduce those risks.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11350935

• MRI and blood tests to predict prostate cancer outcomes after radiation

  This project uses repeated MRI scans and blood-based tumor markers to find early signs that predict how men with intermediate or high-risk prostate cancer do after radiation and hormone therapy.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11308340

• Tiny urine particles that may signal or cause bladder damage after prostate cancer radiation

  Researchers will look at small particles in urine and blood to find markers or mechanisms of bladder damage in men treated with radiation for prostate cancer.

  NIH research University of Rochester · Rochester, United States · NIH-11295418

• Investigating imaging and blood markers to improve prostate cancer treatment outcomes

  This study is looking to help men with intermediate and high-risk prostate cancer who are getting radiation treatment by finding early signs that show how well the treatment is working, using special imaging and blood tests, so doctors can make better decisions about their care.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11168073

• Making prostate cancer radiation treatment safer using genetics

  This work aims to discover genetic markers that can help predict which prostate cancer patients might experience side effects from radiation therapy, allowing for more personalized care.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11123461

• Investigating how tiny particles affect bladder toxicity in prostate cancer patients after radiation treatment

  This study is looking at tiny particles in the body called extracellular vesicles to see if they can help predict bladder problems in prostate cancer patients who have had radiation treatment, with the goal of finding better ways to manage these issues.

  NIH research University of Rochester · Rochester, United States · NIH-11067761

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.