Improving PSMA-RPT Treatment for Advanced Prostate Cancer
Multidimensional analyses to improve PSMA-RPT efficacy in mCRPC
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11122259
This project aims to find better ways to make a special radiation treatment called PSMA-RPT work more effectively for patients with advanced prostate cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11122259 on ClinicalTrials.gov |
What this research studies
We know that a special radiation treatment called PSMA-RPT helps patients with advanced prostate cancer, but it doesn't always work perfectly, and cancer can return. This project is looking closely at the cancer's genes, molecules, and immune system to understand why some treatments work better than others. We are studying how the treatment affects cancer cells and the body's immune response, especially focusing on certain pathways like TP53 and cGAS/STING. Our goal is to discover new ways to make PSMA-RPT more powerful and lasting for patients.
Who could benefit from this research
Good fit: This research is relevant for patients diagnosed with metastatic castration-resistant prostate cancer who are currently receiving or may receive PSMA-RPT.
Not a fit: Patients without metastatic castration-resistant prostate cancer would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies to significantly improve the effectiveness and long-term success of PSMA-RPT for patients with metastatic castration-resistant prostate cancer.
How similar studies have performed: While PSMA-RPT has shown some success in patients, this project explores novel combinations and molecular pathways to enhance its efficacy, building on existing knowledge.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CZERNIN, JOHANNES — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: CZERNIN, JOHANNES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Patient, Cancers