Improving protein stability and function using advanced algorithms
Equipment Supplement to R01GM148610 for an Eppendorf Innova 44R Incubator Shaker
This study is all about making proteins stronger and more effective, using a special computer program to find helpful changes in their structure, and it's aimed at improving medicines and treatments for people who need them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Montana NIH-funded |
| Lab location | 1 site (Missoula, United States) |
| Project ID | NIH-11099203 on NIH RePORTER |
What this research studies
This research focuses on enhancing the stability of proteins by using a specialized algorithm called EmCAST, which predicts beneficial mutations in protein structures. The project aims to apply this algorithm to various protein domains to improve their reliability and functionality. A key aspect of the research involves expressing multiple variants of proteins from E. coli, which requires precise temperature control and shaking conditions provided by a new incubator shaker. By ensuring optimal conditions for protein expression, the research seeks to develop better protein pharmaceuticals and binding agents.
Who could benefit from this research
Good fit: Patients with conditions that could benefit from improved protein pharmaceuticals or therapies, such as genetic disorders or diseases requiring protein replacement, would be ideal candidates.
Not a fit: Patients with conditions unrelated to protein therapies or those who do not require protein-based treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and stable protein-based therapies for various medical conditions.
How similar studies have performed: Previous research has shown success in using computational algorithms to enhance protein stability, indicating a promising approach in this area.
Where this research is happening
Missoula, United States
- University of Montana — Missoula, United States (Active)
Researchers
- Principal investigator: Bowler, Bruce E — University of Montana
- Study coordinator: Bowler, Bruce E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.