Improving protein stability and function using advanced algorithms
Official title: Equipment Supplement to R01GM148610 for an Eppendorf Innova 44R Incubator Shaker
Funded at University of Montana · NIH-11099203 · Data updated 2026-11-12
This study is all about making proteins stronger and more effective, using a special computer program to find helpful changes in their structure, and it's aimed at improving medicines and treatments for people who need them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Montana NIH-funded |
| Lab location | 1 site (Missoula, United States) |
| Project start | September 24, 2022 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $26,337 |
| NIH project number | 3R01GM148610-03S1 |
| Project ID | NIH-11099203 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with conditions that could benefit from improved protein pharmaceuticals or therapies, such as genetic disorders or diseases requiring protein replacement, would be ideal candidates.
✕Less likely to help
Patients with conditions unrelated to protein therapies or those who do not require protein-based treatments may not benefit from this research.
What this research studies
This research focuses on enhancing the stability of proteins by using a specialized algorithm called EmCAST, which predicts beneficial mutations in protein structures. The project aims to apply this algorithm to various protein domains to improve their reliability and functionality. A key aspect of the research involves expressing multiple variants of proteins from E. coli, which requires precise temperature control and shaking conditions provided by a new incubator shaker. By ensuring optimal conditions for protein expression, the research seeks to develop better protein pharmaceuticals and binding agents.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and stable protein-based therapies for various medical conditions.
How similar studies have gone: Previous research has shown success in using computational algorithms to enhance protein stability, indicating a promising approach in this area.
Where this research is happening
-
University of Montana
Missoula, United States Active
Researchers
- Principal investigator: Bowler, Bruce E — University of Montana
- Study coordinator: Bowler, Bruce E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.