Improving protein quality control to address aging-related diseases
Official title: Leveraging ubiquitin-dependent regulatory mechanisms to improve proteome quality in health and disease
Funded at University of California, San Diego · NIH-11042214 · Data updated 2026-11-12
This study is looking at how mistakes in making DNA and proteins can lead to harmful proteins that might cause diseases as we age, and it aims to find ways to boost our body's natural systems that fix these problems, which could help people dealing with age-related health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $590,920 |
| NIH project number | 5R35GM148339-03 |
| Project ID | NIH-11042214 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults experiencing age-related disorders or individuals with conditions linked to protein misfolding and aggregation.
✕Less likely to help
Patients with acute, non-age-related conditions or those without any signs of protein homeostasis issues may not benefit from this research.
What this research studies
This research investigates how errors in DNA and protein production lead to the creation of harmful defective proteins, which can contribute to aging-related diseases. It focuses on enhancing the body's natural quality control systems that manage protein production and degradation. By understanding how these systems work and how they can be manipulated, the research aims to develop strategies to improve health outcomes for individuals suffering from age-related conditions. Patients may benefit from new treatments that enhance or limit protein quality control as needed.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve health and longevity by addressing the root causes of aging-related diseases.
How similar studies have gone: Previous research has shown promising results in enhancing protein quality control mechanisms, indicating potential for success in this novel approach.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Bennett, Eric J — University of California, San Diego
- Study coordinator: Bennett, Eric J
Related research
Other NIH-funded projects on the same topics.
-
Improved MRI guidance for pediatric heart catheterization using autonomous multi-beat image synthesis
Aiming to make MRI-guided pediatric heart catheterizations safer and more reliable by using smart, multi-beat data fusion to produce clearer real-time MRI images.
-
Adapting a combination approach to reduce heavy drinking and boost HIV care and prevention among young men
A pilot project tests a proven program that helps young men cut down on heavy drinking and improves HIV treatment and prevention outcomes.
-
How specific anti-NMDAR1 antibodies in the blood may affect memory and brain protection
This research is exploring whether natural or abnormal anti-NMDAR1 antibodies in the blood influence memory, behavior, and brain protection in humans.
-
Screening and treatment of Chlamydia infection in pregnancy to help prevent preterm birth
This grant studies whether screening pregnant people for Chlamydia trachomatis and treating those who are positive can reduce the risk of preterm birth.
-
Pharmacometrics Core at UC San Diego
A pharmacometrics core is funded to support researchers in analyzing drug data to improve how medicines work for patients.
-
Milk Analytics Core for Precision Dairy Research
A core facility at UC San Diego will provide specialized milk analysis services to support research on dairy biology and human health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.