Improving protein quality control to address aging-related diseases
Leveraging ubiquitin-dependent regulatory mechanisms to improve proteome quality in health and disease
This study is looking at how mistakes in making DNA and proteins can lead to harmful proteins that might cause diseases as we age, and it aims to find ways to boost our body's natural systems that fix these problems, which could help people dealing with age-related health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11042214 on NIH RePORTER |
What this research studies
This research investigates how errors in DNA and protein production lead to the creation of harmful defective proteins, which can contribute to aging-related diseases. It focuses on enhancing the body's natural quality control systems that manage protein production and degradation. By understanding how these systems work and how they can be manipulated, the research aims to develop strategies to improve health outcomes for individuals suffering from age-related conditions. Patients may benefit from new treatments that enhance or limit protein quality control as needed.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing age-related disorders or individuals with conditions linked to protein misfolding and aggregation.
Not a fit: Patients with acute, non-age-related conditions or those without any signs of protein homeostasis issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve health and longevity by addressing the root causes of aging-related diseases.
How similar studies have performed: Previous research has shown promising results in enhancing protein quality control mechanisms, indicating potential for success in this novel approach.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Bennett, Eric J — University of California, San Diego
- Study coordinator: Bennett, Eric J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.