Improving protein crystallization to aid drug design for substance use disorders
Official title: Advanced Nucleation Technologies for Membrane Protein Crystallization to Accelerate Structure-Based Drug Design for Substance Use Disorders
Funded at Denovx, LLC · NIH-10707123 · Data updated 2026-11-12
This study is working on improving the way scientists create tiny crystals of important proteins that help us understand how drugs work in the body, especially for people dealing with substance use disorders, so that we can develop better medications for them.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Denovx, LLC NIH-funded |
| Lab location | 1 site (Streamwood, United States) |
| Project start | September 30, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $711,255 |
| NIH project number | 5R44DA047146-03 |
| Project ID | NIH-10707123 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by substance use disorders who may benefit from new therapeutic options.
✕Less likely to help
Patients with substance use disorders who are not responsive to pharmacological treatments may not see direct benefits from this research.
What this research studies
This research focuses on enhancing the crystallization process of membrane proteins, which are crucial for understanding how drugs interact with the body, particularly in the context of substance use disorders. The team at DeNovX is developing innovative techniques using specialized substrates and engineered features to facilitate the formation of high-quality protein crystals. By successfully crystallizing these proteins, researchers aim to gain insights into their structure, which can lead to more effective drug designs. Patients may benefit from new medications developed through this advanced understanding of drug interactions.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for substance use disorders.
How similar studies have gone: Previous research has shown promise in improving protein crystallization techniques, indicating potential for success in this novel approach.
Where this research is happening
-
Denovx, LLC
Streamwood, United States Active
Researchers
- Principal investigator: Bond, Andrew H. — Denovx, LLC
- Study coordinator: Bond, Andrew H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.