Improving protein analysis for Alzheimer's research
Official title: Soft-Landing of Size-Separated Macromolecules for Structural Analysis by Cryo-TEM
Funded at Nanoengineering Corporation · NIH-11069565 · Data updated 2026-11-12
This study is looking at how proteins related to Alzheimer's disease are structured, using new techniques to help scientists see them better, which could lead to new treatments for the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nanoengineering Corporation NIH-funded |
| Lab location | 1 site (Boca Raton, United States) |
| Project start | June 15, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $338,843 |
| NIH project number | 1R41GM157850-01 |
| Project ID | NIH-11069565 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on enhancing the analysis of protein structures related to Alzheimer's disease using advanced techniques. By employing a method called 'soft-landing,' the researchers aim to separate proteins by size and deposit them onto a sample grid for detailed imaging. This approach utilizes native mass spectrometry and a novel separation technology to preserve protein structures, which is crucial for understanding their role in Alzheimer's. The collaboration between NanoEngineering Corporation and the University of Michigan aims to overcome existing challenges in protein analysis, potentially leading to breakthroughs in drug discovery.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for Alzheimer's disease by providing insights into protein structures involved in the condition.
How similar studies have gone: Previous research has shown promise in using advanced mass spectrometry techniques for protein analysis, indicating potential success for this novel approach.
Where this research is happening
-
Nanoengineering Corporation
Boca Raton, United States Active
Researchers
- Principal investigator: Perez Lorenzo, Luis Javier — Nanoengineering Corporation
- Study coordinator: Perez Lorenzo, Luis Javier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.