Improving prevention and treatment for opioid use disorder and HIV in prisons
Official title: NOTRE: optimizing long-acting pre-exposure prophylaxis and medications for opioid use disorder interventions in carceral settings
Funded at Duke University · NIH-10907969 · Data updated 2026-11-12
This study is looking at how to better provide long-lasting medications for people dealing with opioid use disorder and those at risk for HIV while they are in jail, so they can get the help they need both during their time in custody and when they return to the community.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | May 15, 2024 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,107,431 |
| NIH project number | 1R61DA060583-01 |
| Project ID | NIH-10907969 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who are currently incarcerated and have either opioid use disorder or are at risk for HIV.
✕Less likely to help
Patients who are not incarcerated or do not have opioid use disorder or HIV risk factors may not benefit from this research.
What this research studies
This research focuses on enhancing the delivery of long-acting medications for opioid use disorder and pre-exposure prophylaxis (PrEP) to individuals in carceral settings. It aims to address the high rates of opioid use disorder and HIV among incarcerated populations by developing a co-packaged intervention that combines these treatments. The study will explore how to effectively implement these interventions during incarceration and upon re-entry into the community, ensuring that patients receive the support they need for better health outcomes.
Why it matters
Potential benefit: If successful, this research could significantly reduce the rates of opioid use disorder and HIV among incarcerated individuals, leading to improved health and social outcomes.
How similar studies have gone: Previous research has shown that integrated approaches to treating opioid use disorder and preventing HIV can lead to improved health outcomes, indicating that this approach has potential for success.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Brinkley-Rubinstein, Lauren — Duke University
- Study coordinator: Brinkley-Rubinstein, Lauren
Related research
Other NIH-funded projects on the same topics.
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Systems analysis to improve opioid use disorder care after jail release (SAIA-MOUD)
A program to help people with opioid use disorder get better, faster, and safer care after they leave jail.
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A tiny, targeted drug approach is being developed to help people with opioid use disorder by rewriting the epigenetic signals in the brain to reduce cravings and relapse risk.
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Increasing Access to Medications for Opioid Use Disorder for Unhoused Montanans
This project helps unhoused people in Montana get life-saving medicines for opioid use disorder through clinics connected to syringe service programs, a nurse-led MOUD model, and peer support.
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Optimizing long-acting PrEP and opioid treatment for people in jails and prisons
This project tests a real-world approach to using long-acting PrEP and buprenorphine for HIV prevention and opioid treatment among incarcerated individuals and after release.
-
Scaling up medications for opioid use disorder in residential treatment programs
This grant studies how to help residential treatment programs provide medications for opioid use disorder to reduce overdoses after discharge, focusing on real-world settings and policies.
-
Increasing Capacity at a Native Community Clinic to Improve Opioid Care for urban AI/AN
This grant helps a Native American health clinic build its research capacity to better serve urban American Indian and Alaska Native people dealing with opioid use disorder and related health issues.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.