Improving Pressure Ulcer Healing in Older Adults
TARGETING HIF-1α DYSFUNCTION TO TREAT PRESSURE ULCERS IN THE AGED
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-11087650
This research looks for new ways to help older adults heal from pressure ulcers, also known as bedsores.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11087650 on ClinicalTrials.gov |
What this research studies
Pressure ulcers are a common and costly problem, especially for people over 65. We've learned that aging can weaken the body's natural healing processes, specifically a pathway called HIF-1α. This project aims to understand how HIF-1α changes in the skin of older adults and how these changes affect pressure ulcer healing. We are also exploring if an existing medication, deferoxamine (DFO), can help restore this healing pathway. Our goal is to find better treatments for pressure ulcers in older patients.
Who could benefit from this research
Good fit: This research is particularly relevant for older adults, especially those over 65, who are at risk for or currently have pressure ulcers.
Not a fit: Patients who are not experiencing pressure ulcers or are not in the older adult age group may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new and more effective treatments for pressure ulcers, improving healing and quality of life for older adults.
How similar studies have performed: Previous work has shown that the HIF-1α pathway is important for wound healing and that a specific drug, deferoxamine, can reverse some age-related changes.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GURTNER, GEOFFREY C — UNIVERSITY OF ARIZONA
- Study coordinator: GURTNER, GEOFFREY C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.