Improving PrEP access and daily use for men who sell sex

Efficacy of a PrEP uptake & Adherence Intervention among male sex workers using a 2-stage randomization design

NIH-funded research Brown University · NIH-11080378

This project offers a tailored program to help men who sell sex start PrEP and keep taking it every day.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionBrown University NIH-funded
Lab location1 site (Providence, United States)
Project IDNIH-11080378 on NIH RePORTER

What this research studies

If you join, staff will help you connect with local PrEP clinics using strength-based, motivational sessions that focus on your values and goals. You will also get problem-solving, adherence-focused counseling based on cognitive-behavioral techniques and personalized daily text reminders. The program was developed with input from male sex workers and builds on earlier pilot work. The trial uses a two-stage randomization design so participants may be re-randomized to different levels of support depending on how well the first approach works.

Who could benefit from this research

Good fit: Ideal candidates are HIV-negative men who exchange sex for money, goods, drugs, or other items of value and who are eligible for PrEP.

Not a fit: People who are HIV-positive, not at risk through sex with men, unwilling to use PrEP, or unable to access participating clinics or a phone for texts are unlikely to benefit from enrolling.

Why it matters

Potential benefit: If successful, the program could increase PrEP starts and sustained daily use, lowering participants' risk of HIV.

How similar studies have performed: Earlier pilot work and other programs combining case management, counseling, and text reminders have shown promise, but this larger randomized test is needed to confirm effectiveness.

Where this research is happening

Providence, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.