Improving pregnancy rates in women with endometriosis undergoing IVF treatment
Pre-IVF treatment with a GnRH antagonist in women with endometriosis - A prospective double blind placebo controlled trial (Pregnant)
This study is looking at whether a medication called GnRH antagonist can help women with endometriosis have a baby through IVF by increasing their chances of a live birth, and it will also check if certain markers in the body can help us understand infertility better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10703454 on NIH RePORTER |
What this research studies
This research investigates the effects of a medication called GnRH antagonist on women with endometriosis who are trying to conceive through in vitro fertilization (IVF). The study aims to determine if pre-treatment with this medication can enhance live birth rates compared to a placebo. Participants will be randomly assigned to receive either the medication or a placebo before undergoing IVF. The research also explores the potential of specific biomarkers related to endometriosis to better understand and treat infertility in these women.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with endometriosis who are experiencing infertility and are planning to undergo IVF.
Not a fit: Patients who do not have endometriosis or those who are not seeking IVF treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the chances of live births for women with endometriosis undergoing IVF.
How similar studies have performed: While the use of GnRH agonists has been explored, this approach with GnRH antagonists is novel and has not been extensively tested in this context.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Young, Steven L — Duke University
- Study coordinator: Young, Steven L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.