Improving pregnancy rates in women with endometriosis undergoing IVF treatment
3/4: Pre-IVF treatment with a GnRH antagonist in women with endometriosis - A prospective double blind placebo controlled trial (PREGNANT)
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10684216
This study is looking at whether a new pill can help women with endometriosis have more successful pregnancies through IVF, and it will compare the results of those taking the pill to those taking a sugar pill to see if it really makes a difference.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10684216 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of a new oral medication, a GnRH antagonist, on improving live birth rates in women with endometriosis who are undergoing in vitro fertilization (IVF). The study involves a randomized clinical trial where participants will receive either the medication or a placebo before their IVF treatment. By comparing the outcomes, the researchers aim to determine if this new approach can enhance fertility outcomes for women affected by endometriosis. The study also explores the potential role of specific biomarkers related to endometriosis in predicting treatment success.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with endometriosis who are experiencing infertility and are planning to undergo IVF.
Not a fit: Patients who do not have endometriosis or those who are not seeking IVF treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly increase the chances of live births for women with endometriosis undergoing IVF.
How similar studies have performed: While previous studies have explored the use of GnRH agonists, this research is novel as it focuses on the efficacy of GnRH antagonists specifically for endometriosis-related infertility.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JUNGHEIM, EMILY S — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: JUNGHEIM, EMILY S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.