Improving predictions of tobacco and alcohol use across different ancestries
Official title: Improving cross ancestry polygenic prediction of tobacco and alcohol use
Funded at University of Minnesota · NIH-10908614 · Data updated 2026-11-12
This study is looking at how our genes can help predict who might be at risk for using tobacco and alcohol, so we can create better prevention and treatment plans that work for everyone, no matter their background.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $160,119 |
| NIH project number | 5K01DA057376-02 |
| Project ID | NIH-10908614 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from diverse genetic backgrounds who are at risk for tobacco and alcohol use.
✕Less likely to help
Patients who do not have a history of substance use or are not at risk for tobacco and alcohol use may not benefit from this research.
What this research studies
This research aims to enhance the accuracy of predicting tobacco and alcohol use by analyzing genetic data from a diverse group of individuals. By pooling information from over 3.4 million participants, along with additional genetic data from 2.5 million others, the study seeks to develop polygenic risk scores that can better identify individuals at risk for substance use. This approach will help tailor prevention strategies and treatments based on a person's genetic background, making them more effective. The research focuses on overcoming current limitations in predictive accuracy and applicability across various populations.
Why it matters
Potential benefit: If successful, this research could lead to more personalized prevention and treatment strategies for individuals at risk of substance use disorders.
How similar studies have gone: Previous research has shown promise in using polygenic scores for predicting substance use, but this study aims to improve upon those methods with a more diverse population.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Saunders, Gretchen — University of Minnesota
- Study coordinator: Saunders, Gretchen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.