Improving predictions of side effects from azathioprine treatment
A Personalized Medicine Approach to Improve the Prediction of Azathioprine Toxicity
This study is looking at how your genes might help doctors figure out if you could have serious side effects from the medication azathioprine, which is used for inflammatory conditions, so they can tailor your treatment to keep you safe and healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10783440 on NIH RePORTER |
What this research studies
This research investigates how genetic factors can help predict which patients are at risk for serious side effects from azathioprine, a medication used to treat inflammatory conditions. By analyzing genetic variants beyond the commonly used TPMT testing, the study aims to develop a more comprehensive genetic risk score that can identify patients who may experience myelosuppression or pancreatitis. The research utilizes large biobanks to gather data and improve the accuracy of predictions, ultimately aiming to personalize treatment plans for better safety and efficacy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who are prescribed azathioprine for inflammatory conditions and may be at risk for its side effects.
Not a fit: Patients who are not prescribed azathioprine or those who do not have genetic variations associated with azathioprine toxicity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of severe side effects from azathioprine, leading to safer treatment options for patients.
How similar studies have performed: Other research has shown promise in using genetic testing to predict drug toxicity, suggesting that this approach could lead to meaningful advancements in personalized medicine.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Chung, Cecilia Pilar — University of Miami School of Medicine
- Study coordinator: Chung, Cecilia Pilar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.