Improving prediction of sudden unexpected death in epilepsy
Advancing SUDEP Risk Prediction Using a Multicenter Case-Control Approach
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10888364
This study is looking at what might increase the risk of Sudden Unexpected Death in Epilepsy (SUDEP) to help keep people with epilepsy safer, by examining information from over 40,000 patients to find patterns that could predict this risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10888364 on ClinicalTrials.gov |
What this research studies
This research investigates the risk factors associated with Sudden Unexpected Death in Epilepsy (SUDEP), which is a significant concern for patients with epilepsy. By analyzing data from over 40,000 patients across 86 epilepsy monitoring centers, the study aims to identify clinical factors and biomarkers that could help predict SUDEP risk. The approach includes a retrospective multicenter case-control design, which allows for a larger sample size and more robust findings compared to single-center studies. Patients will be screened for various factors, including seizure types and EEG patterns, to better understand the mechanisms behind SUDEP.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with epilepsy, particularly those experiencing generalized tonic-clonic seizures.
Not a fit: Patients with epilepsy who do not experience seizures or have other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk prediction and preventive strategies for patients with epilepsy, potentially reducing the incidence of SUDEP.
How similar studies have performed: While there have been studies on SUDEP, this multicenter approach is novel and aims to rigorously confirm associations that previous single-center studies could not.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEVINSKY, ORRIN — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: DEVINSKY, ORRIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.