Improving prediction of sudden death in heart disease patients without severe heart dysfunction
PRE-DETERMINE: Advancing Sudden Arrhythmic Death Prediction in Coronary Artery Disease in the Absence of Severe Systolic Dysfunction
This study is looking to find out how to better predict sudden heart problems in people with coronary artery disease who have a functioning heart, so we can help those at risk stay safe and healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11023065 on NIH RePORTER |
What this research studies
This research focuses on understanding and predicting sudden arrhythmic death (SAD) in patients with coronary artery disease who do not have severe systolic dysfunction. The study aims to identify risk factors and develop better predictive models for SAD, particularly in patients with a left ventricular ejection fraction greater than 30-35%. By analyzing a large cohort over a long period, the research seeks to improve the identification of at-risk individuals who may benefit from preventive measures. Patients will be monitored for SAD and other cardiac events to gather comprehensive data on outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with coronary artery disease who have a left ventricular ejection fraction greater than 30-35%.
Not a fit: Patients with severe systolic dysfunction or those not diagnosed with coronary artery disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and prevention strategies for sudden cardiac death in a broader range of heart disease patients.
How similar studies have performed: While there have been studies on sudden cardiac death, this research specifically targets a previously understudied population, making it a novel approach.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Albert, Christine M — Cedars-Sinai Medical Center
- Study coordinator: Albert, Christine M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.