Improving prediction of sudden death in heart disease patients without severe heart dysfunction
Official title: PRE-DETERMINE: Advancing Sudden Arrhythmic Death Prediction in Coronary Artery Disease in the Absence of Severe Systolic Dysfunction
Funded at Cedars-Sinai Medical Center · NIH-11023065 · Data updated 2026-11-12
This study is looking to find out how to better predict sudden heart problems in people with coronary artery disease who have a functioning heart, so we can help those at risk stay safe and healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,521,450 |
| NIH project number | 5R01HL165840-03 |
| Project ID | NIH-11023065 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with coronary artery disease who have a left ventricular ejection fraction greater than 30-35%.
✕Less likely to help
Patients with severe systolic dysfunction or those not diagnosed with coronary artery disease may not benefit from this research.
What this research studies
This research focuses on understanding and predicting sudden arrhythmic death (SAD) in patients with coronary artery disease who do not have severe systolic dysfunction. The study aims to identify risk factors and develop better predictive models for SAD, particularly in patients with a left ventricular ejection fraction greater than 30-35%. By analyzing a large cohort over a long period, the research seeks to improve the identification of at-risk individuals who may benefit from preventive measures. Patients will be monitored for SAD and other cardiac events to gather comprehensive data on outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and prevention strategies for sudden cardiac death in a broader range of heart disease patients.
How similar studies have gone: While there have been studies on sudden cardiac death, this research specifically targets a previously understudied population, making it a novel approach.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Albert, Christine M — Cedars-Sinai Medical Center
- Study coordinator: Albert, Christine M
Related research
Other NIH-funded projects on the same topics.
-
ADAR RNA editing and coronary artery disease: a pathway to new therapies
A scientist-led study at Stanford investigates how changes in RNA editing by ADAR enzymes may drive coronary artery disease and how targeting related pathways could lead to new treatments.
-
ZEB1's role in artery disease and smooth muscle cell changes
This grant studies how the ZEB1 gene affects coronary artery disease by its impact on smooth muscle cells in blood vessels.
-
New imaging methods to improve coronary artery disease diagnosis with dynamic PET
A new PET imaging approach is being tested to measure heart blood flow more accurately in people with suspected coronary artery disease.
-
Understanding why some people with type 1 diabetes get or avoid major heart disease due to genetics
A study looks at genetic factors and immune-related markers to understand why some young people with type 1 diabetes develop major heart disease and others don’t.
-
Multimodal genetic regulation in coronary artery disease
A research grant using advanced genetic and cellular analyses to understand what drives coronary artery disease in diverse populations.
-
Smooth muscle cell programs for coronary artery disease
Researchers are studying how specific gene changes in smooth muscle cells influence coronary artery disease to identify new ways to prevent or treat the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.