Improving phosphate handling in chronic kidney disease
Targeting sKlotho-FGF23 Interactions to Improve Pathological Phosphate Handling in CKD
This study is looking at how two proteins, sKlotho and FGF23, work together to control phosphate levels in people with chronic kidney disease, with the hope of finding new ways to help manage these levels and improve health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10768579 on NIH RePORTER |
What this research studies
This research investigates how the interactions between a protein called sKlotho and another protein, FGF23, affect phosphate levels in patients with chronic kidney disease (CKD). The study aims to understand the molecular mechanisms behind phosphate metabolism and how disruptions can lead to health issues like rickets and fractures. By exploring these interactions, the research seeks to identify potential therapeutic targets that could help manage phosphate levels in CKD patients, ultimately improving their health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic kidney disease who experience issues with phosphate metabolism.
Not a fit: Patients with normal kidney function or those not affected by phosphate metabolism disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better regulate phosphate levels in patients with chronic kidney disease.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways for managing phosphate levels, indicating potential for success in this approach.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: White, Kenneth E — Indiana University Indianapolis
- Study coordinator: White, Kenneth E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.