Improving personalized treatment for depression using cognitive assessments
Official title: ACE-D: Accelerating Cognition-guided signatures to Enhance translation in Depression
Funded at Stanford University · NIH-11083724 · Data updated 2026-11-12
This study is creating a friendly app that helps people with depression by tracking their behavior to better understand their needs and improve their treatment options.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | May 3, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $3,202,745 |
| NIH project number | 5U01MH136062-02 |
| Project ID | NIH-11083724 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults aged 21 and older who are experiencing major depressive disorder and are seeking personalized treatment options.
✕Less likely to help
Patients with depression who are not willing or able to engage with smartphone technology may not benefit from this research.
What this research studies
This research aims to develop a personalized cognitive assessment tool for individuals with depression, addressing the need for better clinical decision-making. By utilizing behavioral measures based on neural mechanisms, the project will create a clinical cognitive signature that can predict treatment outcomes for patients. Participants will engage with a smartphone application that collects behavioral data, allowing for real-time monitoring and tailored treatment options. The study will analyze data from a diverse group of participants, including those with major depressive disorder, to refine these assessments.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for individuals suffering from depression.
How similar studies have gone: Previous research has shown promise in using cognitive assessments and technology for improving treatment outcomes in depression, indicating that this approach could be effective.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Williams, Leanne — Stanford University
- Study coordinator: Williams, Leanne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.