Improving personalized treatment for depression using cognitive assessments

ACE-D: Accelerating Cognition-guided signatures to Enhance translation in Depression

NIH-funded research Stanford University · NIH-11083724

This study is creating a friendly app that helps people with depression by tracking their behavior to better understand their needs and improve their treatment options.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionStanford University NIH-funded
Lab location1 site (Stanford, United States)
Project IDNIH-11083724 on NIH RePORTER

What this research studies

This research aims to develop a personalized cognitive assessment tool for individuals with depression, addressing the need for better clinical decision-making. By utilizing behavioral measures based on neural mechanisms, the project will create a clinical cognitive signature that can predict treatment outcomes for patients. Participants will engage with a smartphone application that collects behavioral data, allowing for real-time monitoring and tailored treatment options. The study will analyze data from a diverse group of participants, including those with major depressive disorder, to refine these assessments.

Who could benefit from this research

Good fit: Ideal candidates for this research include adults aged 21 and older who are experiencing major depressive disorder and are seeking personalized treatment options.

Not a fit: Patients with depression who are not willing or able to engage with smartphone technology may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for individuals suffering from depression.

How similar studies have performed: Previous research has shown promise in using cognitive assessments and technology for improving treatment outcomes in depression, indicating that this approach could be effective.

Where this research is happening

Stanford, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.