Improving pancreatic islet function in type 2 diabetes
Modulating prostaglandin E2 receptor activity to improve pancreatic islet function
['FUNDING_OTHER'] · VETERANS HEALTH ADMINISTRATION · NIH-11098761
This study is looking at how certain receptors in the body can help improve the health of insulin-producing cells in the pancreas, which could lead to better treatments for people with type 2 diabetes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS HEALTH ADMINISTRATION (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11098761 on ClinicalTrials.gov |
What this research studies
This research investigates how modulating specific receptors related to prostaglandin E2 can enhance the function of pancreatic beta cells, which are crucial for insulin production. The study focuses on the roles of EP3 and EP4 receptors, where inhibiting EP3 and activating EP4 may promote beta cell growth and survival. By using both mouse models and human islet cells, the research aims to identify effective treatments that could improve beta cell function in individuals with type 2 diabetes. The ultimate goal is to find new therapeutic strategies that can help manage or reverse the effects of diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes, particularly those who may not respond well to current treatments.
Not a fit: Patients without type 2 diabetes or those with other forms of diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin production and overall management of type 2 diabetes.
How similar studies have performed: Previous research has shown promising results in modulating similar pathways for improving beta cell function, indicating potential for success in this approach.
Where this research is happening
NASHVILLE, UNITED STATES
- VETERANS HEALTH ADMINISTRATION — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GANNON, MAUREEN A — VETERANS HEALTH ADMINISTRATION
- Study coordinator: GANNON, MAUREEN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus