Improving pain management for patients on buprenorphine

Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings

NIH-funded research Boston University Medical Campus · NIH-10561600

This study is testing a new team-based approach to help people who are using buprenorphine for opioid use disorder and also dealing with chronic pain and depression, by comparing a special treatment plan with a health education program to see which one helps improve their pain and overall well-being better.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionBoston University Medical Campus NIH-funded
Lab location1 site (Boston, United States)
Project IDNIH-10561600 on NIH RePORTER

What this research studies

This research focuses on developing a new approach to help patients who are receiving buprenorphine for opioid use disorder and also suffer from chronic pain and depression. The study introduces a collaborative care model called TOPPS, where behavioral health specialists and primary care providers work together to create a unified treatment plan. Participants will receive either the TOPPS intervention or a health education program over three months, with follow-ups for a year to assess the effectiveness of the treatment in improving pain and overall well-being.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals receiving buprenorphine for opioid use disorder who also experience chronic pain and depressive symptoms.

Not a fit: Patients who are not on buprenorphine or do not have chronic pain or depression may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide a novel non-pharmacological treatment option for managing pain and depression in patients undergoing buprenorphine therapy.

How similar studies have performed: Previous pilot studies have shown that similar collaborative care approaches can be feasible and effective, indicating promise for this novel intervention.

Where this research is happening

Boston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.