Improving pain management for knee replacement patients with a new non-invasive device
Official title: Enhancing pain management for knee replacement patients through an innovative non-invasive and opioid-sparing device
Funded at Ncap Medical, LLC · NIH-10921429 · Data updated 2026-11-12
This study is testing a new, non-invasive device called NEUROCUPLE™ to help people manage pain after knee surgery, with the goal of reducing the need for opioid painkillers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ncap Medical, LLC NIH-funded |
| Lab location | 1 site (Heber City, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $416,443 |
| NIH project number | 1R41DA059303-01A1 |
| Project ID | NIH-10921429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals scheduled to undergo total knee replacement surgery.
✕Less likely to help
Patients who are not undergoing knee replacement surgery or those who have contraindications for using the NEUROCUPLE device may not benefit from this research.
What this research studies
This research focuses on developing a non-invasive device called NEUROCUPLE™ to help manage postoperative pain for patients undergoing total knee arthroplasty (TKA). The device aims to reduce the reliance on opioids, which are commonly prescribed for pain relief but can lead to complications and addiction. In a clinical trial, 120 patients will be randomly assigned to receive either the NEUROCUPLE device or a placebo, allowing researchers to evaluate its effectiveness in reducing pain and opioid use after surgery.
Why it matters
Potential benefit: If successful, this research could significantly reduce postoperative pain and the need for opioids in knee replacement patients.
How similar studies have gone: Preliminary studies have shown promise with similar non-pharmacological approaches, indicating potential for success in this area.
Where this research is happening
-
Ncap Medical, LLC
Heber City, United States Active
Researchers
- Principal investigator: Chelly, Jacques E. — Ncap Medical, LLC
- Study coordinator: Chelly, Jacques E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.