Improving Pacing for Heart Failure with Bundle Branch Block
His-Bundle Corrective Pacing in Heart Failure
This research compares a new type of heart pacing called His-bundle corrective pacing with standard treatment for people living with heart failure and a specific electrical issue called right bundle branch block.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11129774 on NIH RePORTER |
What this research studies
For individuals with heart failure and a specific heart rhythm problem called right bundle branch block, standard cardiac resynchronization therapy (BIV-CRT) may not be as effective. This project explores a newer approach, His-bundle corrective pacing (His-CRT), which targets the heart's natural electrical system more directly. We are conducting a clinical trial to see if His-CRT can improve heart function better than BIV-CRT in these patients. The goal is to understand how His-CRT works and if it leads to better outcomes for heart failure patients with this particular condition.
Who could benefit from this research
Good fit: Ideal candidates are individuals with heart failure, severely reduced left ventricular function, a wide QRS on their ECG, and a right bundle branch block ECG pattern.
Not a fit: Patients without heart failure, or those with heart failure but without a right bundle branch block, would likely not benefit from this specific pacing approach.
Why it matters
Potential benefit: If successful, this new pacing method could offer a more effective treatment option for heart failure patients who currently do not respond well to standard therapy due to right bundle branch block.
How similar studies have performed: His-bundle pacing is an emerging technology, and while some preliminary data exist, this randomized trial aims to provide more definitive evidence on its efficacy compared to established methods.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Kutyifa, Valentina — University of Rochester
- Study coordinator: Kutyifa, Valentina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.