Improving ovarian cancer treatment with immunotherapy by targeting PP4
Targeting PP4 to improve ovarian cancer response to immunotherapy
This project looks at how blocking a protein called PP4 might make immunotherapy work better for women with ovarian cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-11146613 on NIH RePORTER |
What this research studies
Ovarian cancer can be very difficult to treat, especially when it resists chemotherapy. This project explores a new way to make existing immunotherapies more effective for these challenging cases. Researchers believe that by targeting a specific protein called PP4, they can help the body's immune system better recognize and fight ovarian cancer cells. The goal is to understand how PP4 affects the cancer's ability to hide from the immune system and how it influences the success of current treatments.
Who could benefit from this research
Good fit: This research is relevant for patients with high-grade serous ovarian cancer, particularly those whose cancer has not responded well to chemotherapy.
Not a fit: Patients with other types of cancer or those whose ovarian cancer is not resistant to chemotherapy may not directly benefit from this specific approach.
Why it matters
Potential benefit: If successful, this work could lead to new treatment strategies that improve how well immunotherapy works for women with ovarian cancer, especially those whose cancer has become resistant to chemotherapy.
How similar studies have performed: The role of PP4 in cancer development and anti-tumor immunity is currently unknown, making this a novel and untested approach.
Where this research is happening
Scottsdale, United States
- Mayo Clinic Arizona — Scottsdale, United States (Active)
Researchers
- Principal investigator: Curtis, Marion — Mayo Clinic Arizona
- Study coordinator: Curtis, Marion
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.