Improving outcomes in patients with sepsis by targeting the gut
Official title: The Gut as a Target to Improve Outcomes in Sepsis
Funded at Emory University · NIH-10990523 · Data updated 2026-11-12
This study is looking at how sepsis impacts gut health in cancer patients, hoping to find new ways to help improve their treatment and recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | February 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $478,890 |
| NIH project number | 5R35GM148217-03 |
| Project ID | NIH-10990523 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill patients, particularly those with cancer, who are at high risk for developing sepsis.
✕Less likely to help
Patients who are not critically ill or do not have cancer may not benefit from this research.
What this research studies
This research investigates how sepsis affects gut health and integrity, particularly in patients with cancer. It aims to understand the mechanisms behind gut dysregulation during sepsis by examining the epithelium, mucosal immune system, and microbiome. By isolating and studying these components, the research seeks to identify potential therapeutic targets to improve patient outcomes. The findings could lead to new strategies for managing sepsis beyond traditional antibiotic treatments.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve survival and recovery for patients suffering from sepsis.
How similar studies have gone: Previous research has shown promising results in targeting gut health to improve outcomes in critically ill patients, indicating that this approach has potential for success.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Coopersmith, Craig M — Emory University
- Study coordinator: Coopersmith, Craig M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.