Improving outcomes for older adults with acute myeloid leukemia through transplantation
Official title: BMT Core - Oregon Health and Science University (OHSU) Consortium
Funded at Oregon Health & Science University · NIH-10936466 · Data updated 2026-11-12
This study is looking at new ways to make stem cell transplants safer and more effective for older adults with acute myeloid leukemia, especially those with other health issues, by using better donor options and treatments to help prevent relapse.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2031 |
| Funding year | 2024 |
| Award (this year) | $244,000 |
| NIH project number | 1UG1HL174405-01 |
| Project ID | NIH-10936466 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 65 and older who are diagnosed with acute myeloid leukemia and are considering allogeneic transplantation.
✕Less likely to help
Patients who are younger than 65 or those with other types of leukemia may not benefit from this research.
What this research studies
This research focuses on enhancing the effectiveness of allogeneic hematopoietic cell transplantation (HCT) for older adults suffering from acute myeloid leukemia (AML). It explores recent advancements in alternative donor transplantation and supportive care, which enable more patients, including those with co-morbidities, to access potentially curative treatments. The study also investigates the use of targeted therapies and improved detection methods for minimal residual disease (MRD) to identify patients at high risk of relapse, aiming to optimize treatment regimens and improve overall outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better survival rates and quality of life for older adults with acute myeloid leukemia.
How similar studies have gone: Other research has shown promising results with similar approaches in improving outcomes for patients undergoing transplantation for hematologic malignancies.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Maziarz, Richard Thomas — Oregon Health & Science University
- Study coordinator: Maziarz, Richard Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.