Improving organ transplant success by enhancing immune response
Targeting trained immunity in transplantation
['FUNDING_P01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11064088
This study is looking at ways to help organ transplants work better by training the body's immune system to accept the new organ more easily, which could lead to fewer problems and better recovery for patients.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11064088 on ClinicalTrials.gov |
What this research studies
This research investigates how to improve the success of organ transplants by focusing on a concept called trained immunity, which enhances the body's innate immune response. The approach involves understanding how certain immune cells can be trained to respond better to transplanted organs, potentially leading to better graft survival and fewer side effects from current immunosuppressive therapies. By studying the underlying mechanisms of trained immunity, researchers aim to develop new strategies that could reduce the risk of organ rejection and improve overall patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are undergoing or have undergone organ transplantation and are at risk of organ rejection.
Not a fit: Patients who are not candidates for organ transplantation or those with stable grafts and no history of rejection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for organ transplant recipients, improving their chances of long-term graft survival.
How similar studies have performed: Other research has shown promise in enhancing immune responses through trained immunity, suggesting that this approach could lead to significant advancements in transplantation.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FAYAD, ZAHI A. — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: FAYAD, ZAHI A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.