Improving organ transplant success by enhancing immune response
Official title: Targeting trained immunity in transplantation
Funded at Icahn School of Medicine at Mount Sinai · NIH-11064088 · Data updated 2026-11-12
This study is looking at ways to help organ transplants work better by training the body's immune system to accept the new organ more easily, which could lead to fewer problems and better recovery for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $3,010,650 |
| NIH project number | 5P01AI168258-03 |
| Project ID | NIH-11064088 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are undergoing or have undergone organ transplantation and are at risk of organ rejection.
✕Less likely to help
Patients who are not candidates for organ transplantation or those with stable grafts and no history of rejection may not benefit from this research.
What this research studies
This research investigates how to improve the success of organ transplants by focusing on a concept called trained immunity, which enhances the body's innate immune response. The approach involves understanding how certain immune cells can be trained to respond better to transplanted organs, potentially leading to better graft survival and fewer side effects from current immunosuppressive therapies. By studying the underlying mechanisms of trained immunity, researchers aim to develop new strategies that could reduce the risk of organ rejection and improve overall patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for organ transplant recipients, improving their chances of long-term graft survival.
How similar studies have gone: Other research has shown promise in enhancing immune responses through trained immunity, suggesting that this approach could lead to significant advancements in transplantation.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Fayad, Zahi a. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Fayad, Zahi a.
Related research
Other NIH-funded projects on the same topics.
-
Improving Breast Cancer Guideline Adherence in Nigeria
Aimed at helping doctors in Nigeria follow international guideline-based breast cancer care to improve outcomes for women with breast cancer.
-
Genetically Validated PCOS Subtypes for Better Diagnosis and Risk Stratification
Aimed at women with polycystic ovary syndrome (PCOS), this project uses genetic data and patient characteristics to define distinct PCOS subtypes and improve how we diagnose and estimate risk.
-
Closed-loop control of interneuron timing to influence seizures and memory in epilepsy
A study tests a brain-quieting system that uses light to precisely time certain brain cells in epilepsy-prone mice to see if this can lessen seizures and improve memory.
-
Understanding why some brain regions and cells accumulate tau in Alzheimer’s and related diseases
Researchers are studying why certain brain areas and neuron types accumulate tau protein in Alzheimer’s and related conditions, and how this leads to brain changes and symptoms.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
Aging and brain injury connection: learning how late-life TBI relates to Alzheimer’s and related dementias
This grant looks at whether traumatic brain injuries in people 65 and older are linked to Alzheimer’s disease and related dementias, using a large, harmonized set of long-term aging studies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.