Improving nitric oxide levels to help treat preeclampsia
Restoration of reduced nitric oxide bioavailability in Preeclampsia
This study is looking at a new medication called AKT-1005 that could help treat preeclampsia, a serious condition during pregnancy, by making sure it works well in the body, so it can better protect both moms and their babies.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10870378 on NIH RePORTER |
What this research studies
This research focuses on developing a new treatment for preeclampsia, a serious pregnancy complication characterized by high blood pressure and potential harm to both mother and baby. The team is working on a drug called AKT-1005, which has shown promise in laboratory models but faces challenges with its solubility and stability. To address these issues, they will create and test new formulations of AKT-1005 to ensure it can be effectively delivered in the body. If successful, this treatment could significantly improve outcomes for pregnant individuals affected by preeclampsia.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals diagnosed with preeclampsia.
Not a fit: Patients who are not pregnant or those without a diagnosis of preeclampsia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment that reduces the risks associated with preeclampsia for pregnant individuals.
How similar studies have performed: Previous research has shown promise in using nitric oxide donors for treating preeclampsia, indicating that this approach has potential based on earlier findings.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Zsengeller, Zsuzsanna Kinga — Beth Israel Deaconess Medical Center
- Study coordinator: Zsengeller, Zsuzsanna Kinga
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.