Improving neutrophil function to enhance outcomes in sepsis
Official title: CD11c as a novel target to improve neutrophil effector functions and sepsis outcome
Funded at Boston Children's Hospital · NIH-11001937 · Data updated 2026-11-12
This study is looking at how a protein called CD11c helps improve the way certain immune cells, called neutrophils, work to fight infections, especially in people with sepsis, with the hope of finding better treatments to help them recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $343,785 |
| NIH project number | 5R01GM148392-03 |
| Project ID | NIH-11001937 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with sepsis, particularly those experiencing severe immune response issues.
✕Less likely to help
Patients with non-infectious causes of sepsis or those who do not have a significant immune response may not benefit from this research.
What this research studies
This research investigates the role of CD11c, a specific protein, in enhancing the function of neutrophils, which are crucial immune cells that help fight infections. The study aims to understand how CD11c influences neutrophil maturation and effectiveness, particularly in patients suffering from sepsis, a severe and often life-threatening condition. By exploring this relationship, the research seeks to identify new therapeutic strategies that could improve patient outcomes in sepsis. The approach involves both laboratory experiments and potential clinical applications to enhance neutrophil responses.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for sepsis, potentially reducing mortality rates and enhancing recovery for affected patients.
How similar studies have gone: Previous research has indicated the importance of neutrophil function in sepsis, suggesting that targeting CD11c could be a promising approach, although this specific investigation is relatively novel.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Yuki, Koichi — Boston Children's Hospital
- Study coordinator: Yuki, Koichi
Related research
Other NIH-funded projects on the same topics.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
-
STeroids and enhanced Antibiotics for sepsis in Africa with HIV/TB (STARS)
This grant tests whether adding steroids and stronger antibiotics helps adults with severe sepsis tied to HIV/TB in areas with high TB rates.
-
Steroids and better antibiotics for sepsis in people with AIDS in Africa
This study tests whether adding hydrocortisone and stronger antibiotics can improve survival for adults with sepsis who also have AIDS or advanced immune suppression in regions with high TB.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Role of MMP3 in heart dysfunction during sepsis
This research tests whether blocking MMP3 can protect the heart and improve survival during sepsis in adults.
-
Sepsis patient care guided by Ugandan-wide immune profiling
A large NIH-funded study will map how the immune system behaves during sepsis in people in Uganda to improve personalized care for sepsis patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.