Improving neutrophil function to enhance outcomes in sepsis
CD11c as a novel target to improve neutrophil effector functions and sepsis outcome
This study is looking at how a protein called CD11c helps improve the way certain immune cells, called neutrophils, work to fight infections, especially in people with sepsis, with the hope of finding better treatments to help them recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11001937 on NIH RePORTER |
What this research studies
This research investigates the role of CD11c, a specific protein, in enhancing the function of neutrophils, which are crucial immune cells that help fight infections. The study aims to understand how CD11c influences neutrophil maturation and effectiveness, particularly in patients suffering from sepsis, a severe and often life-threatening condition. By exploring this relationship, the research seeks to identify new therapeutic strategies that could improve patient outcomes in sepsis. The approach involves both laboratory experiments and potential clinical applications to enhance neutrophil responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with sepsis, particularly those experiencing severe immune response issues.
Not a fit: Patients with non-infectious causes of sepsis or those who do not have a significant immune response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for sepsis, potentially reducing mortality rates and enhancing recovery for affected patients.
How similar studies have performed: Previous research has indicated the importance of neutrophil function in sepsis, suggesting that targeting CD11c could be a promising approach, although this specific investigation is relatively novel.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Yuki, Koichi — Boston Children's Hospital
- Study coordinator: Yuki, Koichi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.