Improving nerve regeneration using modified stem cells
Stem Cell Surface Modification to Promote Nerve Regeneration
This study is looking at how special modified stem cells from fat can help heal nerve injuries better, with the hope of creating new treatments that make recovery easier for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10758224 on NIH RePORTER |
What this research studies
This research focuses on enhancing the recovery of peripheral nerve injuries through the use of modified human adipose stem cells (hASCs). The team aims to improve the adhesion and differentiation of these stem cells by applying a novel surface modification technique. By optimizing specific sugar analogs, they will evaluate how these modified stem cells can promote nerve regeneration in laboratory settings and eventually in clinical applications. The ultimate goal is to develop effective therapies that can significantly improve patient outcomes following nerve injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced critical-sized peripheral nerve injuries and are seeking innovative treatment options.
Not a fit: Patients with non-peripheral nerve injuries or those who do not have significant nerve damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from nerve injuries, potentially restoring function and improving quality of life.
How similar studies have performed: Previous research has shown promise in using stem cell therapies for nerve regeneration, but this specific approach utilizing surface modification techniques is relatively novel.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Jia, Xiaofeng — University of Maryland Baltimore
- Study coordinator: Jia, Xiaofeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.