Improving nerve regeneration after spinal cord injuries
Official title: Regulated PTEN expression to overcome barriers to corticospinal tract regeneration after spinal cord injury
Funded at University of Louisville · NIH-10861304 · Data updated 2026-11-12
This study is looking at ways to help nerves in the spinal cord heal better after an injury, especially those that help with movement, by adjusting certain proteins and using techniques to encourage nerve growth, all aimed at improving recovery for people with spinal cord injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $391,250 |
| NIH project number | 1R01NS132773-01A1 |
| Project ID | NIH-10861304 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have experienced spinal cord injuries affecting their ability to move voluntarily.
✕Less likely to help
Patients with spinal cord injuries that are not amenable to regeneration or those with other complicating health conditions may not benefit from this research.
What this research studies
This research investigates how to enhance the regrowth of nerve pathways in the spinal cord after injuries, particularly focusing on the corticospinal tract, which is crucial for voluntary movement. The approach involves manipulating the expression of a protein called PTEN, which normally inhibits nerve growth, and using a method to degrade molecules that block regeneration. By controlling these factors, the research aims to promote axon regeneration and improve functional recovery in patients with spinal cord injuries. The study will evaluate the timing and effects of these interventions to ensure safety and effectiveness.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and mobility for individuals with spinal cord injuries.
How similar studies have gone: Previous research has shown promise in using similar approaches to enhance nerve regeneration, indicating potential for success in this novel application.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Metcalfe, Mariajose — University of Louisville
- Study coordinator: Metcalfe, Mariajose
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.