Improving nerve health to reduce pain from chemotherapy
Official title: Targeting Schwann cell dysfunction and repair signaling in chemotherapy induced painful peripheral neuropathy
Funded at New York University · NIH-10856514 · Data updated 2026-11-12
This study is looking at how to help people with painful nerve damage from chemotherapy by focusing on special cells that support nerve health, with the hope of finding new ways to ease their pain while still allowing them to receive their cancer treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $2,833,086 |
| NIH project number | 1R01DE033674-01 |
| Project ID | NIH-10856514 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients experiencing painful peripheral neuropathy as a side effect of chemotherapy.
✕Less likely to help
Patients who are not undergoing chemotherapy or do not experience peripheral neuropathy may not benefit from this research.
What this research studies
This research focuses on understanding and addressing the painful nerve damage caused by chemotherapy, known as chemotherapy-induced painful peripheral neuropathy (CIPPN). It investigates the role of Schwann cells, which are crucial for nerve function, and how their dysfunction contributes to pain. The study aims to enhance the survival and function of these cells through specific signaling pathways, potentially leading to new treatments that alleviate pain without requiring a reduction in chemotherapy. By targeting the underlying mechanisms of nerve damage, the research seeks to improve the quality of life for patients undergoing cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments that reduce pain and improve the quality of life for cancer patients receiving chemotherapy.
How similar studies have gone: Previous research has shown promise in targeting similar pathways for nerve repair and pain relief, indicating potential for success in this approach.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Ye, Yi — New York University
- Study coordinator: Ye, Yi
Related research
Other NIH-funded projects on the same topics.
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Non-invasive, microscopic biomarkers to detect CIPN in chemotherapy patients
This grant aims to develop a non-invasive imaging method to measure nerve changes in patients undergoing chemotherapy to better understand and monitor chemotherapy-induced peripheral neuropathy (CIPN).
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Longitudinal study of how body-sense relates to chemotherapy nerve damage
This study follows people with breast or gastrointestinal cancer and healthy controls to see if brain processing of body sensations contributes to chemotherapy-induced nerve damage.
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A new screen for chemotherapy-related nerve problems in young children
A clinician-scientist at Yale is developing a child-friendly survey to quickly screen for nerve-related side effects from cancer treatment in kids from birth to age 5.
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How the immune system’s CD4+ T cells in women might prevent chemotherapy-related nerve pain
A study in mice explores whether female immune cells in nerve tissue can lessen pain from chemotherapy, with potential implications for preventing CIPN in women.
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Axonal transport and chemotherapy-related nerve pain
This grant studies why certain cancer patients develop painful nerve damage from chemotherapy and explores ways to prevent or treat it.
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Remote monitoring and nurse follow-up to manage chemotherapy-induced peripheral neuropathy
A program uses symptom reporting tools with nurse follow-up to reduce and better manage chemotherapy-induced neuropathy for cancer survivors, during and after treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.