Improving nerve block techniques for pain and autonomic dysfunction treatment
Official title: Optimized Electrical Block of Peripheral Nerves
Funded at Duke University · NIH-11004991 · Data updated 2026-11-12
This study is looking at new ways to use electrical signals to help block pain in people with conditions like chronic pain, heart failure, and diabetes, aiming to make the treatment safer and more effective for those who need better options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | January 15, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $493,777 |
| NIH project number | 5R01NS126376-03 |
| Project ID | NIH-11004991 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from chronic pain conditions or autonomic dysfunctions such as heart failure or diabetes.
✕Less likely to help
Patients with conditions unrelated to nerve function or those who do not experience chronic pain or autonomic dysfunction may not benefit from this research.
What this research studies
This research focuses on enhancing electrical nerve block methods to effectively target small diameter nerve fibers associated with chronic pain and autonomic dysfunctions like heart failure and diabetes. By optimizing the design of waveforms and electrodes, the study aims to reduce the energy needed for nerve block, minimize adverse responses during the procedure, and selectively block specific nerve fibers without affecting larger ones. The research involves rigorous engineering and in vivo testing in both small and large animal models to ensure clinical applicability. Patients may benefit from improved pain management and treatment options for conditions that currently have limited therapeutic approaches.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic pain and autonomic dysfunction, improving patients' quality of life.
How similar studies have gone: Previous research has shown promise in nerve block techniques, but this approach aims to address specific challenges that have not been fully explored.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Grill, Warren M. — Duke University
- Study coordinator: Grill, Warren M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.