Improving nasal function in patients with unilateral cleft lip deformity
Computational modeling of the mature unilateral cleft lip nasal deformity for objective assessment of patient nasal function and treatment outcomes
This study is working on a new way to help people with a cleft lip breathe better through their nose by figuring out where blockages happen and improving surgery to fix those issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10369059 on NIH RePORTER |
What this research studies
This research focuses on developing a computational modeling platform to assess and improve nasal function in patients with unilateral cleft lip nasal deformity. By identifying specific sites of airway obstruction caused by structural abnormalities, the project aims to enhance surgical outcomes for these patients. The approach involves detailed analysis of nasal airflow and obstruction, which has been historically overlooked in cleft lip treatment. Ultimately, the goal is to restore normal nasal breathing function in individuals who have undergone cleft lip repair.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of unilateral cleft lip repair who experience nasal breathing difficulties.
Not a fit: Patients without a history of cleft lip or those who do not experience nasal obstruction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for patients by restoring normal nasal breathing function.
How similar studies have performed: While the approach of using computational modeling for nasal function assessment is innovative, similar methodologies have shown promise in other areas of surgical treatment outcomes.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Frank-Ito, Dennis Onyeka — Duke University
- Study coordinator: Frank-Ito, Dennis Onyeka
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.