Improving myelin formation in hereditary neuropathies by targeting cholesterol transport
Official title: Targeting the ABCA1 cholesterol transporter to correct pathophysiological myelin formation in hereditary neuropathies
Funded at University of Nevada Reno · NIH-11040596 · Data updated 2026-11-12
This study is looking at how cholesterol movement in the body helps build myelin, which is important for healthy nerve function, and it aims to find new treatments for people with hereditary neuropathies by focusing on a specific cholesterol transporter.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $352,073 |
| NIH project number | 1R61NS136656-01A1 |
| Project ID | NIH-11040596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with hereditary neuropathies, particularly those with abnormalities in the PMP22 gene.
✕Less likely to help
Patients with non-hereditary neuropathies or those without specific genetic abnormalities related to PMP22 may not benefit from this research.
What this research studies
This research focuses on understanding how cholesterol transport affects the formation of myelin, which is crucial for proper nerve function. It investigates the role of the ABCA1 cholesterol transporter in correcting myelin formation in patients with hereditary neuropathies. By exploring the relationship between cholesterol metabolism and myelin production, the research aims to develop new therapeutic approaches that could restore normal myelin function. Patients may be involved in trials that assess the effectiveness of these new treatments.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve nerve function and reduce symptoms in patients with hereditary neuropathies.
How similar studies have gone: While the approach of targeting cholesterol transport for myelin repair is innovative, similar strategies have shown promise in other neurological conditions, suggesting potential for success.
Where this research is happening
-
University of Nevada Reno
Reno, United States Active
Researchers
- Principal investigator: Notterpek, Lucia — University of Nevada Reno
- Study coordinator: Notterpek, Lucia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.