Improving muscle repair for Becker Muscular Dystrophy
Official title: Membrane repair as a therapeutic intervention for treating Becker Muscular Dystrophy
Funded at Myofinity Biosciences INC · NIH-11005455 · Data updated 2026-11-12
This study is testing a new protein treatment designed to help repair muscle cells for people with Becker Muscular Dystrophy, with the hope of improving muscle function and easing symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Myofinity Biosciences INC NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 23, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $811,438 |
| NIH project number | 4R42AR083329-02 |
| Project ID | NIH-11005455 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Becker Muscular Dystrophy, particularly those experiencing muscle weakness and related symptoms.
✕Less likely to help
Patients with other forms of muscular dystrophy or those without a diagnosis of Becker Muscular Dystrophy may not benefit from this research.
What this research studies
This research focuses on developing a new protein therapy aimed at enhancing the repair of muscle cell membranes in patients with Becker Muscular Dystrophy (BMD). The approach involves engineering a modified version of a protein called rhMG53, which plays a crucial role in muscle cell membrane repair. By optimizing this protein's properties, the research aims to create a treatment that can restore muscle function and alleviate symptoms associated with BMD. The project will gather essential data to support the application for FDA approval of this new therapy.
Why it matters
Potential benefit: If successful, this research could lead to a novel treatment that significantly improves muscle function and quality of life for patients with Becker Muscular Dystrophy.
How similar studies have gone: Previous research has shown promise with similar protein therapies in treating muscular dystrophies, indicating a potential for success in this novel approach.
Where this research is happening
-
Myofinity Biosciences INC
Boston, United States Active
Researchers
- Principal investigator: Weisleder, Noah — Myofinity Biosciences INC
- Study coordinator: Weisleder, Noah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.