Improving muscle recovery in heart failure patients with protein supplements
Official title: A SkeleTal muscle Recovery Intervention with Dietary protein in Heart Failure (ASTRID-HF)
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11145647 · Data updated 2026-11-12
This study is looking at whether adding more protein to the diet can help people with heart failure build muscle and feel better, while also checking how it affects their overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | March 15, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $273,754 |
| NIH project number | 5R01HL167113-03 |
| Project ID | NIH-11145647 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with heart failure with reduced ejection fraction.
✕Less likely to help
Patients who do not have heart failure or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the effects of oral protein supplementation on muscle mass and physical function in patients with heart failure with reduced ejection fraction (HFrEF). It aims to determine whether increasing dietary protein can reverse muscle loss and improve survival rates among these patients. The study will involve a randomized controlled trial to assess the effectiveness of this intervention, while also exploring the underlying biological mechanisms of muscle wasting in HFrEF. Patients will be monitored for changes in muscle mass and overall health outcomes over the course of the trial.
Why it matters
Potential benefit: If successful, this research could lead to improved muscle recovery and enhanced quality of life for patients suffering from heart failure.
How similar studies have gone: Previous research has shown promising results in muscle recovery interventions for heart failure patients, suggesting that this approach may be effective.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Vest, Amanda Ruth — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Vest, Amanda Ruth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.