Improving muscle recovery after severe injuries using a special scaffold and medication
Acquiring Nanoparticle Tracking Analysis System to Enhance Lab Productivity and Capability
This study is looking for ways to help people recover better from serious muscle injuries by using a special scaffold to support muscle healing and a medication to reduce inflammation, making it easier for your body to repair itself.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11035834 on NIH RePORTER |
What this research studies
This research focuses on enhancing the recovery of skeletal muscle after significant injuries that result in a loss of muscle tissue. It aims to develop a biomimetic scaffold made of extracellular matrix proteins that can be implanted to support muscle regeneration. Additionally, the study will explore the sustained release of an FDA-approved immunosuppressant drug, FK-506, to reduce inflammation and improve healing. By also targeting specific helper T cells that aid in muscle repair, the research seeks to create a comprehensive approach to treating volumetric muscle loss.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced significant muscle injuries resulting in volumetric muscle loss.
Not a fit: Patients with minor muscle injuries or those without significant muscle loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective therapies for patients suffering from severe muscle injuries, significantly improving their recovery and quality of life.
How similar studies have performed: Previous research has shown promise in using biomimetic scaffolds and immunomodulatory strategies for muscle regeneration, indicating a potential for success in this approach.
Where this research is happening
Saint Louis, United States
- Saint Louis University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Garg, Koyal — Saint Louis University
- Study coordinator: Garg, Koyal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.