Improving muscle recovery after severe injuries
Proregenerative Immunotherapies for Volumetric Muscle Loss
This study is looking for ways to help people heal better after serious muscle injuries by using a special treatment that combines new healing techniques and immune system support, making it easier for muscles to recover and grow back stronger.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10579498 on NIH RePORTER |
What this research studies
This research focuses on developing new therapies to help recover muscle tissue after significant injuries that result in volumetric muscle loss (VML). It combines regenerative techniques with immunomodulatory strategies to enhance muscle repair. The approach involves using a special scaffold made from extracellular matrix proteins that releases an FDA-approved drug to reduce inflammation and promote healing. Additionally, the study aims to identify specific immune cells that can aid in muscle regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced significant muscle loss due to severe injuries.
Not a fit: Patients with minor muscle injuries or those whose muscle loss is not classified as volumetric may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments for patients suffering from severe muscle injuries, improving their recovery and quality of life.
How similar studies have performed: Previous research has shown promise in using similar regenerative and immunomodulatory approaches for muscle repair, indicating potential for success in this area.
Where this research is happening
Saint Louis, United States
- Saint Louis University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Garg, Koyal — Saint Louis University
- Study coordinator: Garg, Koyal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.