Improving muscle mass and fitness in young cancer survivors through exercise and supplements
Official title: Intensive tailored exercise training with NAD+ precursor supplementation to improve muscle mass and fitness in adolescent and young adult survivors of hematopoietic stem cell transplantation
Funded at Children's Hosp of Philadelphia · NIH-10914104 · Data updated 2026-11-12
This study is designed to help young people who have had stem cell transplants stay strong and healthy by combining personalized exercise programs with special supplements, making it easier for them to keep their muscle and fitness levels up at home.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $650,940 |
| NIH project number | 5R01CA254955-04 |
| Project ID | NIH-10914104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents and young adults who have undergone hematopoietic stem cell transplantation and are experiencing muscle loss.
✕Less likely to help
Patients who have not undergone hematopoietic stem cell transplantation or those who are not experiencing muscle mass loss may not benefit from this research.
What this research studies
This research focuses on helping adolescent and young adult survivors of hematopoietic stem cell transplantation (HCT) who are at risk of losing muscle mass and fitness. The approach combines tailored exercise training with supplementation of NAD+ precursors to enhance muscle function and overall health. Participants will engage in home-based aerobic and resistance training, which has been shown to improve muscle strength and metabolism. The study aims to address the unique challenges faced by these survivors in maintaining their physical health post-treatment.
Why it matters
Potential benefit: If successful, this research could significantly improve the physical health and quality of life for young cancer survivors by increasing their muscle mass and fitness levels.
How similar studies have gone: Previous research has shown that exercise and NAD+ precursor supplementation can effectively improve muscle function in other populations, suggesting a promising approach for this unique group.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Mostoufi-Moab, Sogol — Children's Hosp of Philadelphia
- Study coordinator: Mostoufi-Moab, Sogol
Related research
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Tailored exercise plus NAD+ supplement to rebuild muscle and fitness in adolescent and young adult stem-cell transplant survivors
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T Cell Precursors to Restore Immune Power After Stem Cell Transplants
This grant supports a patient-friendly approach to speed up immune recovery after a stem cell transplant by giving patients donor‑made T cell precursors that mature into healthy immune cells.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.