Improving muscle health and activity after sepsis with targeted nutrition
Official title: Targeted nutritional approach to restore muscle health and physical activity after sepsis
Funded at Texas A&m University · NIH-10780497 · Data updated 2026-11-12
This study is looking at how certain nutritional supplements can help people recovering from sepsis regain their muscle strength and get back to being active, using pigs to learn more about the best ways to support recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $457,498 |
| NIH project number | 1R01GM152626-01 |
| Project ID | NIH-10780497 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill patients who have been diagnosed with sepsis and are experiencing muscle weakness and reduced physical activity.
✕Less likely to help
Patients who are not critically ill or who have not experienced sepsis may not benefit from this research.
What this research studies
This research investigates how specific nutritional interventions can help restore muscle health and physical activity in patients recovering from sepsis, a serious condition that can lead to long-term muscle weakness. The study will utilize animal models, particularly pigs, to understand the mechanisms of muscle breakdown and the effectiveness of a combined nutritional formulation that includes β-hydroxy β-methylbutyric acid and essential amino acids. By identifying the best nutritional strategies, the research aims to enhance rehabilitation outcomes for critically ill patients. The findings could lead to new nutritional guidelines for improving recovery after sepsis.
Why it matters
Potential benefit: If successful, this research could significantly improve recovery and quality of life for patients who have experienced sepsis by restoring muscle function and increasing physical activity.
How similar studies have gone: Previous research has shown promise in using targeted nutritional approaches to improve recovery in critically ill patients, suggesting that this study builds on established concepts.
Where this research is happening
-
Texas A&m University
College Station, United States Active
Researchers
- Principal investigator: Deutz, Nicolaas E — Texas A&m University
- Study coordinator: Deutz, Nicolaas E
Related research
Other NIH-funded projects on the same topics.
-
Role of blood flow mechanics and transfusion in sepsis-related tiny-cl vessel clots
A patient-focused look at how red blood cell flow and transfusions might influence tiny blood vessel clots and organ problems in sepsis.
-
STeroids and enhanced Antibiotics for sepsis in Africa with HIV/TB (STARS)
This grant tests whether adding steroids and stronger antibiotics helps adults with severe sepsis tied to HIV/TB in areas with high TB rates.
-
Steroids and better antibiotics for sepsis in people with AIDS in Africa
This study tests whether adding hydrocortisone and stronger antibiotics can improve survival for adults with sepsis who also have AIDS or advanced immune suppression in regions with high TB.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Role of MMP3 in heart dysfunction during sepsis
This research tests whether blocking MMP3 can protect the heart and improve survival during sepsis in adults.
-
Sepsis patient care guided by Ugandan-wide immune profiling
A large NIH-funded study will map how the immune system behaves during sepsis in people in Uganda to improve personalized care for sepsis patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.