Improving muscle function in patients with heart failure
Targeting Skeletal Muscle Perfusion and Oxidative Capacity in HFpEF
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11077258
This study is looking at ways to help people with heart failure feel stronger and exercise better by checking how their muscles use oxygen and blood flow during light activities, and it will test different treatments to see if they can boost muscle performance and everyday activity levels.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11077258 on ClinicalTrials.gov |
What this research studies
This research investigates how to enhance skeletal muscle performance in patients with Heart Failure with Preserved Ejection Fraction (HFpEF) by measuring muscle oxygen use and blood flow. Using advanced MRI techniques, the study aims to understand how these factors affect exercise endurance in patients. The research will involve testing different treatments to see if they can improve muscle function and overall physical activity levels. By focusing on submaximal exercise, the study aims to reflect the daily challenges faced by patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Heart Failure with Preserved Ejection Fraction (HFpEF) who experience difficulty with physical activities.
Not a fit: Patients with heart failure types other than HFpEF or those with severe comorbidities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve exercise capacity and quality of life for patients with HFpEF.
How similar studies have performed: Previous research has shown promising results in improving muscle function through similar metabolic interventions, indicating potential for success in this approach.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZAMANI, PAYMAN — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: ZAMANI, PAYMAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.