Improving muscle and nerve function in older adults
Official title: Improving Aged Neuromuscular Health and Function
Funded at Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab · NIH-11085939 · Data updated 2026-11-12
This study is exploring whether using young muscle cells can help older adults regain better movement and muscle health, making everyday activities easier and improving their quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | June 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $449,454 |
| NIH project number | 5R01AG073223-04 |
| Project ID | NIH-11085939 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related decline in muscle and nerve function.
✕Less likely to help
Patients who are younger than 21 or do not have age-related neuromuscular issues may not benefit from this research.
What this research studies
This research investigates how age-related decline in neuromuscular function can be improved using stem cell therapy. The approach involves transplanting muscle-derived stem cells from young mice into older mice to restore nerve and muscle health. By understanding the molecular pathways involved, the researchers aim to develop a treatment that could enhance mobility and quality of life for older adults. The study focuses on the potential of these stem cells to rejuvenate the aging neuromuscular system and improve daily functioning.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly enhance mobility and independence in older adults.
How similar studies have gone: Previous research has shown promising results with similar stem cell therapies in animal models, indicating potential for success in human applications.
Where this research is happening
-
Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
Chicago, United States Active
Researchers
- Principal investigator: Lavasani, Mitra — Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
- Study coordinator: Lavasani, Mitra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.