Improving MRI techniques to monitor brain tumors in children
Quantitative MRI for Pediatric Optic Pathway Glioma Treatment Response
This study is working on new MRI technology to help doctors better track how well treatments are working for kids with optic pathway gliomas, a type of brain tumor linked to neurofibromatosis type 1, so they can make quicker and smarter decisions about their care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10894916 on NIH RePORTER |
What this research studies
This research focuses on developing advanced MRI techniques to better assess treatment responses in children with optic pathway gliomas, a type of brain tumor commonly associated with neurofibromatosis type 1. The study aims to create a three-dimensional MRI-based application that utilizes machine learning to provide more accurate and automated measurements of tumor volume over time. By improving the way these tumors are monitored, the research seeks to enhance clinical trials and treatment strategies for affected children. Patients will be monitored using this innovative imaging approach to ensure timely and effective treatment adjustments.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with optic pathway gliomas, particularly those with neurofibromatosis type 1.
Not a fit: Patients with brain tumors other than optic pathway gliomas or those outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective monitoring and treatment of brain tumors in children, potentially preserving their vision and improving overall outcomes.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques for tumor assessment, but this specific application of three-dimensional MRI for pediatric optic pathway gliomas is novel.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Avery, Robert Andrew — Children's Hosp of Philadelphia
- Study coordinator: Avery, Robert Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.