Improving MRI techniques to better detect Alzheimer's disease
Improving the sensitivity and specificity of MRI-based biomarkers in Alzheimer's disease
This study is working on improving how we spot early signs of Alzheimer's disease using regular MRI scans, so we can help people even before they show symptoms and make treatments more effective.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11053644 on NIH RePORTER |
What this research studies
This research aims to enhance the detection of Alzheimer's disease (AD) by developing more effective MRI-based biomarkers. It focuses on analyzing standard MRI scans to identify early signs of AD, even before symptoms appear. By using advanced computational methods, the study seeks to quantify changes in specific brain regions associated with AD, which could lead to more accurate assessments of disease progression and treatment efficacy. This approach is crucial for conducting clinical trials that target the earliest stages of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease, particularly those in the presymptomatic or early symptomatic stages.
Not a fit: Patients with advanced Alzheimer's disease or those without any risk factors for the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate detection of Alzheimer's disease, improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown promise in using MRI biomarkers for Alzheimer's detection, indicating that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Yushkevich, Paul a. — University of Pennsylvania
- Study coordinator: Yushkevich, Paul a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.