Improving MRI imaging using advanced nanoparticle technology
Official title: Photo-hyperpolarized 13C MRI
Funded at Adamas Nanotechnologies, INC. · NIH-10922686 · Data updated 2026-11-12
This study is testing a new type of MRI technology that uses special tiny particles to create clearer images of deep tissues, which could help doctors better understand diseases and improve how they diagnose and treat patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Adamas Nanotechnologies, INC. NIH-funded |
| Lab location | 1 site (Raleigh, UNITED STATES) |
| Project start | September 28, 2022 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $333,773 |
| NIH project number | 5R01GM143626-03 |
| Project ID | NIH-10922686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals requiring advanced imaging for deep tissue conditions or diseases.
✕Less likely to help
Patients with superficial conditions that do not require deep tissue imaging may not benefit from this research.
What this research studies
This research focuses on enhancing magnetic resonance imaging (MRI) capabilities by developing a new class of hyperpolarized 13C nanoparticle probes. These probes aim to improve imaging resolution in deep tissue environments, which is crucial for understanding disease mechanisms. The approach involves using fluorescent nanodiamonds with nitrogen-vacancy centers to significantly boost the MRI signal, allowing for better visualization of biological processes. Patients may benefit from more accurate imaging techniques that can lead to improved diagnosis and treatment planning.
Why it matters
Potential benefit: If successful, this research could provide patients with more precise imaging techniques that enhance disease detection and monitoring.
How similar studies have gone: While the use of hyperpolarized MRI techniques is emerging, this specific approach using fluorescent nanodiamonds is relatively novel and has not been widely tested.
Where this research is happening
-
Adamas Nanotechnologies, INC.
Raleigh, United States Active
Researchers
- Principal investigator: Shenderova, Olga a — Adamas Nanotechnologies, INC.
- Study coordinator: Shenderova, Olga a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.