Improving MRI imaging of oxygen levels in various diseases
Official title: Enabling systemic delivery of europium-containing contrast agents for magnetic resonance imaging
Funded at Wayne State University · NIH-10996302 · Data updated 2026-11-12
This study is working on new ways to improve MRI scans by using special agents that help doctors see oxygen levels in the body better, which can help with diagnosing and treating conditions like cancer and kidney problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | May 10, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $578,863 |
| NIH project number | 1R01EB035631-01A1 |
| Project ID | NIH-10996302 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from conditions related to hypoxia, such as certain cancers, kidney diseases, or neurological disorders.
✕Less likely to help
Patients with conditions that do not involve hypoxia or those who are not undergoing imaging procedures may not benefit from this research.
What this research studies
This research focuses on developing new contrast agents that can be delivered throughout the body to enhance magnetic resonance imaging (MRI) of oxygen levels, which is crucial for diagnosing and treating diseases like cancer and kidney disorders. The team aims to overcome current limitations in the delivery of europium-based agents by improving their stability and effectiveness in the bloodstream. By creating hypoxia-sensing probes, this research seeks to provide better diagnostic tools for conditions linked to low oxygen levels in tissues.
Why it matters
Potential benefit: If successful, this research could lead to more accurate imaging techniques that help in the early detection and treatment of various diseases associated with hypoxia.
How similar studies have gone: Previous research has shown promise in developing hypoxia-responsive contrast agents, indicating that this approach has potential for success.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Allen, Matthew J — Wayne State University
- Study coordinator: Allen, Matthew J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.