Improving movement after spinal cord injury by targeting specific nerve cells
Official title: Medial deep dorsal glycinergic interneurons as a target for improving locomotion following spinal cord injury
Funded at Drexel University · NIH-10902343 · Data updated 2026-11-12
This study is looking at how we can help people with spinal cord injuries move better by targeting specific nerve cells in the spinal cord that control movement, with the hope of finding new ways to improve walking and mobility.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31NS135913-01A1 |
| Project ID | NIH-10902343 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have experienced a spinal cord injury, particularly at the cervical or thoracic levels.
✕Less likely to help
Patients with spinal cord injuries that do not affect locomotion or those with complete injuries may not benefit from this research.
What this research studies
This research investigates how certain inhibitory nerve cells in the spinal cord can be targeted to improve movement in individuals who have suffered a spinal cord injury. The study focuses on understanding the changes that occur in the spinal cord circuits after injury and how these changes affect locomotion. By examining the role of specific interneurons that regulate sensory input, the research aims to develop strategies to restore proper control of movement. Patients may benefit from new therapeutic approaches that enhance their ability to walk and move more effectively.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for restoring movement in patients with spinal cord injuries.
How similar studies have gone: Previous research has shown promising results in targeting spinal cord circuits for improving locomotion, indicating that this approach has potential for success.
Where this research is happening
-
Drexel University
Philadelphia, United States Active
Researchers
- Principal investigator: Mcgrath, Jenna — Drexel University
- Study coordinator: Mcgrath, Jenna
Related research
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This project looks at swallowing problems and chronic aspiration in adults with traumatic neck spine injuries to find patterns that could prevent serious lung complications.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.