Improving mood and cognitive function after stroke using a digital intervention
Official title: Efficacy and target engagement of a digital intervention to improve the depression-executive dysfunction syndrome after stroke
Funded at Weill Medical Coll of Cornell Univ · NIH-10873174 · Data updated 2026-11-12
This study is testing a new online program to help improve mood and thinking skills for people who have had a stroke, making it easier for them to feel better and manage their daily lives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $195,480 |
| NIH project number | 5K23MH129849-03 |
| Project ID | NIH-10873174 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a stroke and are suffering from depression and executive dysfunction.
✕Less likely to help
Patients who have not had a stroke or do not exhibit symptoms of depression or cognitive dysfunction may not benefit from this research.
What this research studies
This research aims to develop and evaluate a digital intervention designed to improve mood and cognitive function in patients who have experienced a stroke. The project focuses on understanding the brain mechanisms behind mood disorders and uses advanced imaging techniques to assess how well the intervention engages these targets. By providing a remote and accessible treatment option, the research seeks to address the challenges faced by stroke survivors dealing with depression and executive dysfunction. The approach includes mentorship and training for the principal investigator to ensure a robust and effective study design.
Why it matters
Potential benefit: If successful, this research could lead to more effective and accessible treatments for mood and cognitive issues following a stroke.
How similar studies have gone: While there is ongoing research in this area, the specific use of a digital intervention for post-stroke mood and cognitive dysfunction is relatively novel.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Jaywant, Abhishek — Weill Medical Coll of Cornell Univ
- Study coordinator: Jaywant, Abhishek
Related research
Other NIH-funded projects on the same topics.
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Combining rTMS and aerobic exercise to help post-stroke depression and walking
A new approach tests whether adding aerobic exercise to rTMS can reduce depression after stroke and improve walking.
-
Understanding why post-stroke depression happens in older mice
A study in aged mice investigates how stroke can lead to depression and what biological changes drive it, with a focus on the roles of oxytocin and taurine.
-
rTMS plus aerobic exercise for post‑stroke depression and walking recovery
This project combines repetitive transcranial magnetic stimulation (rTMS) with aerobic exercise to try to reduce depression and improve walking for people after a stroke.
-
Understanding Depression After Stroke
This project explores how depression develops after a stroke, especially in older individuals, by looking at brain changes and potential protective factors.
-
Preventing depression in older stroke survivors through behavioral activation
This study is testing a friendly online program designed to help older adults who have had a stroke stay active and engaged in enjoyable activities to prevent feelings of depression, especially for those who may be struggling financially.
-
Understanding how stroke affects depression in older mice
This study is looking at how a stroke can lead to depression in older mice, focusing on how the body's immune response and inflammation play a role, and it hopes to find ways to use natural substances like oxytocin and taurine to help improve mood and recovery for people who have had a stroke.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.