Improving models for studying head and neck cancer treatments
Improving the translational value of head and neck cancer patient-in-mouse models
This study is looking at how to improve models that use patient tumor samples to better understand head and neck cancer, so we can find out how different ways of growing these tumors in mice can help us learn more about their growth and how they respond to treatments, ultimately aiming to improve care for patients like you.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10875595 on NIH RePORTER |
What this research studies
This research focuses on enhancing the effectiveness of patient-derived models used to study head and neck cancer. By using tumor samples from patients, the researchers aim to better understand how different methods of implanting these tumors in mice affect their growth and response to treatments. The study will investigate various factors that influence tumor biology and therapy response, ultimately aiming to create more accurate models that can lead to better patient care. The research combines innovative techniques with thorough assessments to ensure that the findings are relevant to human patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with head and neck cancer who are undergoing surgical treatment.
Not a fit: Patients with other types of cancer or those who are not undergoing surgical treatment for head and neck cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for head and neck cancer patients by improving the predictive value of preclinical models.
How similar studies have performed: Previous research has shown that improving the methodologies of patient-derived models can enhance their relevance and predictive power, indicating a promising avenue for this study.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Kimple, Randall J. — University of Wisconsin-Madison
- Study coordinator: Kimple, Randall J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.