Improving mitochondrial health for spinal cord injury treatment
Enhanced Mitochondrial Viability via Engineered Hyrdogels for Intrathecal Spinal Cord Delivery
['FUNDING_R01'] · UNIVERSITY OF KENTUCKY · NIH-10874706
This study is testing a new gel that can deliver healthy mitochondria to help heal spinal cord injuries, aiming to improve recovery for patients by tackling the damage caused by the injury.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KENTUCKY (nih funded) |
| Locations | 1 site (LEXINGTON, UNITED STATES) |
| Trial ID | NIH-10874706 on ClinicalTrials.gov |
What this research studies
This research focuses on addressing mitochondrial dysfunction that occurs after a spinal cord injury (SCI), which can lead to further cellular damage. The team aims to develop a special hydrogel that can deliver healthy mitochondria directly to the injury site, potentially improving recovery. By combining this delivery method with existing treatments that enhance mitochondrial function and reduce oxidative stress, the researchers hope to create a more effective therapeutic approach. Patients may benefit from this innovative method that targets the root causes of damage following SCI.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently suffered a spinal cord injury and are experiencing mitochondrial dysfunction.
Not a fit: Patients with chronic spinal cord injuries or those who do not have mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and functional outcomes for patients with spinal cord injuries.
How similar studies have performed: Previous research has shown promise in mitochondrial transplantation and enhancing mitochondrial function, suggesting potential for success with this novel approach.
Where this research is happening
LEXINGTON, UNITED STATES
- UNIVERSITY OF KENTUCKY — LEXINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PATEL, SAMIRKUMAR — UNIVERSITY OF KENTUCKY
- Study coordinator: PATEL, SAMIRKUMAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cellular injury