Improving methotrexate treatment for childhood non-infectious uveitis
Official title: Optimizing methotrexate use for the management of chronic pediatric non-infectious uveitis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11308671 · Data updated 2026-11-12
Finding signs that predict which children with chronic non-infectious uveitis will benefit from methotrexate so they can get the right medicine sooner.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2026 |
| Award (this year) | $560,861 |
| NIH project number | 5R01EY034565-04 |
| Project ID | NIH-11308671 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with chronic non-infectious uveitis who are about to start methotrexate and whose families can attend clinic visits and testing.
✕Less likely to help
Children with infectious uveitis, patients who are not starting methotrexate, or adults outside the pediatric age range would not be eligible and are unlikely to benefit directly from this study.
What this research studies
If your child is starting methotrexate for chronic non-infectious uveitis, this study will follow them over time to see who improves. Doctors will collect clinical information, blood for gene-expression testing, and repeat advanced eye imaging to look for patterns linked to success or failure with methotrexate. The team plans to enroll about 120 children and compare baseline features and imaging changes between those who respond and those who do not. Results are intended to help guide faster, more personalized treatment decisions to protect vision.
Why it matters
Potential benefit: If successful, doctors could identify children unlikely to respond to methotrexate earlier and move them to more effective biologic treatments before vision is harmed.
How similar studies have gone: Studies using imaging and gene-expression markers in other inflammatory diseases have shown promise, but using them to predict methotrexate response in pediatric uveitis is a relatively new approach.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Angeles-Han, Sheila Therese — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Angeles-Han, Sheila Therese
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.