Improving methotrexate treatment for childhood non-infectious uveitis
Optimizing methotrexate use for the management of chronic pediatric non-infectious uveitis
Finding signs that predict which children with chronic non-infectious uveitis will benefit from methotrexate so they can get the right medicine sooner.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11308671 on NIH RePORTER |
What this research studies
If your child is starting methotrexate for chronic non-infectious uveitis, this study will follow them over time to see who improves. Doctors will collect clinical information, blood for gene-expression testing, and repeat advanced eye imaging to look for patterns linked to success or failure with methotrexate. The team plans to enroll about 120 children and compare baseline features and imaging changes between those who respond and those who do not. Results are intended to help guide faster, more personalized treatment decisions to protect vision.
Who could benefit from this research
Good fit: Children with chronic non-infectious uveitis who are about to start methotrexate and whose families can attend clinic visits and testing.
Not a fit: Children with infectious uveitis, patients who are not starting methotrexate, or adults outside the pediatric age range would not be eligible and are unlikely to benefit directly from this study.
Why it matters
Potential benefit: If successful, doctors could identify children unlikely to respond to methotrexate earlier and move them to more effective biologic treatments before vision is harmed.
How similar studies have performed: Studies using imaging and gene-expression markers in other inflammatory diseases have shown promise, but using them to predict methotrexate response in pediatric uveitis is a relatively new approach.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Angeles-Han, Sheila Therese — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Angeles-Han, Sheila Therese
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.